Fighting Back Hypermutation
Fighting Back Hypermutation
Viviana Simon
NULL
*Correspondence: Viviana Simon, Email not available
Abstract
A new mechanism that cells use to fightinfection with HIV-1 is becoming more apparent.The identification of the human geneAPOBEC3G (initially referred to as CEM15) asthe target of the HIV-1 Vif (viral infectivity factor)in 2002 (Sheehy, et al., 2002) spurred a seriesof studies aimed towards unraveling the piecesand parts of this host defense mechanism. Thelong sought-after Vif substrate, APOBEC3G,bears homology with a group of mammalianproteins with RNA editing activity that can leadto the introduction of genetic modifications inmRNA through DNA deamination.
