Emergence of AZT Resistance Taking d4T
Emergence of AZT Resistance Taking d4T
Pablo Barreiro
Department of Infectious Diseases, Hospital Carlos III-La Paz University Hospital. Madrid, Spain
*Correspondence: Pablo Barreiro, Email not available
Abstract
The activity of antiretroviral drugs seems to becompromised in some extent when compounds ofthe same family are used in second-line therapies.For instance, the antiviral effect of d4T is reduced inpersons previously exposed to AZT. Two main reasonshave been associated with this observation.First, a reduction in the phosphorylation of d4T afterAZT exposure, since both AZT and d4T are thymidineanalogues, and share the same phosphorylationpathways.
