Anti-atherogenic Effects of Nevirapine

Several reports in the literature have highlightedthe impact of lipid disorders on the outcomeof subjects on antiretroviral therapy. In arecent study, investigators from Wisconsin (Stein,et al. Circulation 2001;104:257-62) demonstratedthat the use of protease inhibitor (PI)-containingregimens is associated with atherogenic lipoproteinchanges and endothelial dysfunction, both ofwhich predispose to atherosclerosis and furthercardiovascular risk. In a cross-sectional study theauthors examined a total of 37 adults with HIVinfection who were receiving antiretroviral therapy.