Do Regulatory T-Cells Play a Role in AIDS Pathogenesis?
Adriano Boasso 1, Monica Vaccari 1, Jakob Nilsson 1, Gene M. Shearer 1, Jan Andersson 1, Valentina Cecchinato 1, Claire Chougnet 1, Genoveffa Franchini 1
1 NULL
*Correspondence: Adriano Boasso, Email not available
Abstract
The impairment of adaptive immune responses to HIV and abnormalities in the immune regulatoryfunction mechanisms during HIV infection have been regarded as key issues in AIDS pathogenesissince the early years of the pandemic. However, the multiple mechanisms underlying this impairmentare still not fully understood. New emerging information shows that alterations in the number and/orfunction of regulatory T-cells may contribute to HIV pathogenesis. Thus, pharmacologic manipulationof regulatory T-cells as well as blocking the activity of other immunomodulatory molecules, such asindoleamine 2,3-dioxygenase, glucocorticoid-induced tumor necrosis factor receptor and PD1, mightprovide a valuable approach to redirect the immune system towards an efficient antiviral response.
