The PD-1/PDL-1 Pathway: Another Magic Bullet for HIV Therapy?
The PD-1/PDL-1 Pathway: Another Magic Bullet for HIV Therapy?
Mario Clerici 1, Monica Vaccari 1, Adriano Boasso 1, Valentina Cecchinato 1, Gene M. Shearer 1, Genoveffa Franchini 1
1 NULL
*Correspondence: Adriano Boasso, Email not available
Abstract
The PD-1/PDL-1 Pathway: Another Magic Bullet for HIV Therapy?
An effective immune response to pathogensresults from activation of T-cells by antigen-presentingcells. The T-cell activation is positivelyregulated by T-cell receptor ligation and the interactionof the CD28/B7 and other co-stimulatorymolecules. Negative regulators include theCTLA-4/B7 and the PD-1/PDL-1 molecules.
