Clinical Impact of Minor Drug-resistant Virus Populations on Treatment Response
Clinical Impact of Minor Drug-resistant Virus Populations on Treatment Response
Carmen de Mendoza
Puerta de Hierro University Hospital, Madrid, Spain
*Correspondence: Carmen de Mendoza, Email not available
Abstract
Transmitted drug-resistant HIV can compromiseinitial antiretroviral therapy; therefore, its detection isimportant for patient management, and accordingly,guidelines recommend drug resistance testing beforeinitiating HAART (Hirsch, et al. Clin Infect Dis.2008;47:266-85). The absence of drug pressure inantiretroviral-naive persons may cause transmitteddrug-resistant viruses to decline to levels undetectable by conventional bulk sequencing, persistingonly as minority drug-resistant variants (Briones andDomingo. AIDS Rev. 2008;10:93-109).
