Heterogeneity in the Response to Antiretroviral Therapy
Amalio Telenti 1, Miguel Muñoz 1, Gabriela Bleiber 1, Bruno Ledergerber 1, Daniel Kaufmann 1
1 NULL
*Correspondence: Amalio Telenti, Email not available
Abstract
The dynamics of viral suppression and the quality of immune reconstitution after initiation of potent antiretroviral therapy may vary considerably from person to person. The heterogeneity of response reflects a summation of viral and host factors. Thus, analysis of the different responses may provide clues on the biology of viral replication under the constrains of drug pressure, or on critical aspects of the mechanisms of CD4 T-cell depletion. On the clinical side, decisions on treatment switch or discontinuation might need to take into account unexpected benefits from suboptimal therapy. There is also an urgent need for understanding the phenomenon of progressive immunosuppression after exhausting all available treatment combinations.
