HIV Escape at Late Stage may be Due to the Lack of V3 Loop Carbohydrates
HIV Escape at Late Stage may be Due to the Lack of V3 Loop Carbohydrates
Kristel van Laethem
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*Correspondence: Kristel van Laethem, Email not available
Abstract
Most of the neutralising antibodies present in thesera of HIV-1 infected patients are directed againstthe V3 loop of gp120 or to the epitopes overlappingthe CD4-binding sites of gp120 (Chamat S et al. JImmunol 1992;149:649-54; Burton D. Proc NatlAcad Sci USA 1997;94:10018-23). A point mutationwithin the epitope, or a point mutation elsewherein the env gene that alters the conformationof the epitope, can result in resistance towards theneutralisation activity of antibodies (Park E et al. JVirol 1998;72:7099-107).
