Promising New Inhibitors of HIV Coreceptors
Promising New Inhibitors of HIV Coreceptors
Anne-Mieke Vandamme
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*Correspondence: Anne-Mieke Vandamme, Email not available
Abstract
Ever since their discovery in 1996, chemokine receptorswhich act as HIV coreceptors have been aninteresting new target for drug development. Thefirst class of CXCR4 targeted drugs, the non-peptidicbicyclams, were discovered in 1992 (De Clercqet al. PNAS 89:5286-90), long before its precisemechanism of action was unraveled (Schols et al. JExp Med 1997;186:1383-8).
