An Old Virus Using Chemokine Receptors to Enter Cells Might have Selected for Resistance to HIV Infection
An Old Virus Using Chemokine Receptors to Enter Cells Might have Selected for Resistance to HIV Infection
Anne-Mieke Vandamme
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*Correspondence: Anne-Mieke Vandamme, Email not available
Abstract
Chemokine receptors are known to act as coreceptorsfor HIV. Now Lalani et al. (Science 1999;286: 1966-71) have reported that chemokine receptors(CCR1, CXCR4, or CCR5) are also the receptorsfor myxoma poxvirus. Non-permissive mouse cellstransfected with chemokine receptor expressionvectors became permissive to myxoma poxvirus infection.This infection could be blocked by highconcentrations of RANTES, the natural ligand ofCCR5.
