Indirect Impacts of Tat on HIV mRNA Capping
Indirect Impacts of Tat on HIV mRNA Capping
Dirk Daelemans
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*Correspondence: Dirk Daelemans, Email not available
Abstract
The viral RNA expression of HIV-1 is greatly increasedthrough the function of one of its regulatorproteins, the transactivator Tat. It augmentslevels of viral RNA by increasing transcriptionalelongation. For function, Tat requires a cis-actingRNA element, TAR, located at the 5’ end of all viraltranscripts. Through interaction with TAR, Tatre c ruits pTEFb, a cyclin T associated kinase (CDK9)complex, to the preinitiation transcription complex.
