The Emergence of Peptides as Therapeutic Drugs for the Inhibition of HIV-1
The Emergence of Peptides as Therapeutic Drugs for the Inhibition of HIV-1
Alexandra Hüther 1, Ursula Dietrich 1
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*Correspondence: Alexandra Hüther, Email not available
Abstract
Due to their small size and specific binding properties, peptides are very suited to interfere withprotein-protein interactions and thus are ideal drug candidates aiming at such targets in the complexcellular interactome. Peptides can easily be selected from natural or artificial peptide libraries for anytarget and further optimized by in silico analysis, chemical synthesis, and the introduction of nonnaturalamino acids. Here we review the current status of peptide drugs with special emphasis onthe inhibition of HIV-1. (AIDS Rev. 2007;9:208-17)Corresponding author: Ursula Dietrich, ursula.dietrich@em.uni-frankfurt.de
Keywords: HIV-1. Therapeutic peptides. Peptidomimetic.
