The Challenge of HIV-1 Antiretroviral Resistance in Africa in the Era of HAART
Hakim Sendagire 1, Philippa J. Easterbrook 1, Immaculate Nankya 1, Eric J. Arts 1, David Thomas 1, Steven J. Reynolds 1
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*Correspondence: David Thomas, Email not available
Abstract
Antiretroviral therapy programs in Africa are currently providing treatment for almost two million people.The long-term success of large scale antiretroviral therapy programs in sub-Saharan Africa remainsuncertain because of the limited information currently available on rates of virologic failure and selectionfor drug-resistant variants in the different HIV subtypes. This article provides a comprehensivereview of the published literature on the prevalence of primary and secondary HIV drug resistance withdifferent subtypes and in various settings across sub-Saharan Africa.
