New ARV Guidelines from the IAS-USA Panel
Pablo Barreiro 1, Pablo Labarga 2
1 Department of Infectious Diseases, Hospital Carlos III-La Paz University Hospital. Madrid, Spain; 2 NULL
*Correspondence: Pablo Barreiro, Email not available
Abstract
An updated version of the IAS-USA panel antiretroviral treatment guidelines was released in July 2010 (Thompson M, et al. JAMA. 2010;304:321-33). A new spirit with a wider openness to different treatment options emanates from this document in comparison with older versions. The consideration of two aspects largely explains this new view. First, the appreciation that uncontrolled HIV replication is associated with deleterious immune activation and inflammatory processes that ultimately accelerates damage of multiple organs, causing, among others, an increase in cardiovascular risk, neurological deterioration, etc. Second, the much more potent antiviral activity and safer profile of the newer antiretroviral drugs has permitted building unprecedented robust and convenient drug combinations.
