Vectored Immunoprophylaxis – An Innovative Approach to Prevent HIV Infection
Eduardo Seclén
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA
*Correspondence: Eduardo Seclén, Email not available
Abstract
Despite the numerous efforts made to develop aneffective vaccine, immunization against HIV infectionremains an elusive goal. Vaccine trials performed todate have shown either no efficacy or even a trendtowards a higher infection in the vaccinated population(Cohen, et al. Science. 2007;318(5853):1048-9). Theonly exception was reported by the so-called âThaiTrialâ?, which showed a protective effect in 31% ofindividuals receiving the combined vaccine RV144(Rerks-Ngarm, et al. New Engl J Med. 2009;361(23):2209-20). This rate of protective effect, althoughsignificant and encouraging for the HIV vaccinationfield, is far from desirable to provide a global effectiveprotection.
