A Novel HIV-1 Inhibitor Targeting gp 120-CD4 Interactions
A Novel HIV-1 Inhibitor Targeting gp 120-CD4 Interactions
Dominique Schols
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*Correspondence: Dominique Schols, Email not available
Abstract
Investigators from Bristol-Myers Squibb haverecently published several manuscripts on asmall molecule inhibitor of HIV entry. The compoundis called BMS-378806, and represents anew class of HIV inhibitor that binds directly tothe HIV-1 envelope gp120, and by this effect, itinhibits the CD4 receptor binding (Ling, et al.PNAS 2003;100:11013-8; Guo, et al. J Virol2003;77:10528-36).
