The First Integrase Inhibitors are Coming
The First Integrase Inhibitors are Coming
Vicente Soriano
UNIR Health Sciences School and Medical Center, Universidad Internacional de La Rioja, Madrid, Spain
*Correspondence: Vicente Soriano. Email: vicente.soriano@unir.net
Abstract
At the XI International HIV Drug ResistanceWorkshop held in Seville last July, investigatorsfrom Merck reported the first steps towardsthe clinical use of HIV integrase inhibitors(Hazuda, et al. & Young, et al. AntiviralTher 2002;7:3 and 17). Integrase is a virallyencoded enzyme that inserts (integrates) thedouble-stranded DNA product of reverse transcriptioninto the DNA of the host cell chromosome.
