Regulation of HIV-1 Gene Expression by Histone Acetylation and Factor Recruitment at the LTR Promoter
Regulation of HIV-1 Gene Expression by Histone Acetylation and Factor Recruitment at the LTR Promoter
Carine van Lint
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*Correspondence: Carine van Lint, Email not available
Abstract
The packaging of eukaryotic DNA into chromatinplays an active role in transcriptional regulation byinterfering with the accessibility of the transcriptionfactors to DNA. Nucleosome structure is modulatedby posttranslational covalent modifications of thehistone tails (including acetylation), and by the actionof ATP-dependent chromatin remodeling complexes.High histone acetylation level at the promoterof genes is generally associated with transcriptionalactivation.
