Off-label use of antiretroviral drugs: ethical and legal implications for clinical decision-making

Introduction The summary of product characteristics is the primary source for determining the specific conditions of use of a medicinal product. Therapeutic innovation is progressing at a pace that far exceeds the updating of marketing authorizations. Off-label medicinal products are also referred to as authorised medicinal products used under conditions other than those approved or […]

Hantavirus outbreak in a cruise departing from Argentina

The World Health Organization has confirmed ten cases including three deaths of hantavirus infection on the Dutch cruise ship Hondius, which anchored in Cape Verde during the first days of May 2026. He had left on March 20 from Ushuaia, in the Argentina Tierra del Fuego. Its destination was the Canary Islands. Three weeks after […]

Antiretroviral therapy “à la carte

The World Health Organization (WHO) estimates that more than 41 million people are currently living with HIV infection worldwide. Every year, about 1.3 million new infections occur (UNAIDS 2025). Antiretroviral treatment has improved dramatically over the past 30 years, so that there are hardly any cases of AIDS in people with access to the medication. […]

Dolutegravir shows efficacy in HTLV-1 infection

HTLV-1 is a retrovirus that infects humans and is biologically close to HIV, the AIDS virus. Both are transmitted sexually, vertically, and parenterally. HTLV-1 may produce clinical manifestations in 10% of carriers, which characteristically include adult T-cell leukemia/lymphoma (ATLL) and a subacute neurological disease known as tropical spastic paraparesis or HTLV-1 associated myelopathy (HAM). The […]